Don’t miss next week’s B.S.R.C. Alexander Fleming ERA Chair Scientific Seminar entitled: “A quantum leap of understanding of protein clustering and function by single molecule studies and machine learning analysis” by Prof Nikos S. Hatzakis
🗓️ Thursday, January 25, 2024, 12:00pm
📍 Venue: B.S.R.C Fleming Lecture Theatre
Protein dynamics, spatiotemporal localization, and interaction with biomolecular entities underlie and control biological function. Single-particle studies have enabled the direct imaging and quantitative analysis of dynamic biological processes with nanometer spatial and millisecond temporal resolution, revealing dynamic behaviors such as protein clustering and aggregation, cell entry pathways and trafficking of biologicals previously masked in ensemble averaging. This heterogeneity while important for biology, imposes considerable analytic challenges.
The team of Prof Hatzakis has developed and applied powerful methodologies to track the spatiotemporal localization of biomolecular entities, their oligomerization and aggregation, the cell entry pathways of biologicals and utilized this information to design and optimize their targeted delivery directly or with nanocontainers. To analyse the complex, multidimensional, multiterabyte data we acquire, we have employed novel methodologies based on machine learning that offer rapid precise and automated transition from raw microcopy images to quantitative biomedicine insights accelerating discoveries often by 106 times.
In his talk, Prof Hatzakis will focus on some of their recent studies to observe in real time protein aggregation and oligomerization as well as how the optimized delivery of pharmaceuticals can regulate these processes.