Dr. Z. Faidon Brotzakis, Senior Post-Doctoral Researcher at Skretas Lab, in collaboration with Dr. Maria Milanesi and Prof. Michele Vendruscolo from the Department of Chemistry at the University of Cambridge, recently published a study in Science Advances entitled “Transient Interactions Between the Fuzzy Coat and the Cross-β Core of Brain-Derived Aβ42 Filaments.” Their research employs a multidisciplinary approach, combining cryo-EM data with Molecular Dynamics simulations, to characterize the structural dynamics of Alzheimer’s Disease brain-derived amyloid filaments formed by Aβ42.

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