📅 March 12-14, 2025
We are excited to announce that Dr. Georgios Skretas, Director of the Institute for Bio-Innovation at the Biomedical Sciences Research Center “Alexander Fleming”, will be presenting at NextGen Biomed 2025.
Talk Title:
“Engineering Microbes for the Discovery of Cyclic Oligopeptide Rescuers of Pathogenic Protein Misfolding & Aggregation: Challenges & Opportunities”
Talk Description:
Protein misfolding and aggregation are fundamental processes underlying numerous human diseases, including neurodegenerative disorders. Dr. Skretas will present a novel bacterial platform developed by his team that enables the efficient biosynthesis of molecular libraries with expanded diversities, combined with direct functional screening to identify chemical rescuers of disease-related protein misfolding and aggregation.
In addition to these advances, Dr. Skretas will address broader efforts related to biocatalysis and oligonucleotide manufacturing, including:
- Efforts to utilize biocatalysis to improve scalability for oligonucleotide production aimed at large therapeutic applications.
- Convergent strategies employing enzymatic ligation and smaller oligonucleotide fragments to enhance conventional synthesis approaches.
- Modeling data showing that these strategies can significantly reduce manufacturing costs and environmental impact, achieving up to 65% reduction in amidite use and 74% reduction in solvent consumption.
We can’t wait for this exciting conference, which brings together leading researchers, biotech innovators, and industry experts to discuss the latest breakthroughs in biomedical research, synthetic biology, and therapeutic development.
Looking forward to an inspiring NextGen Biomed 2025 — March 12-14!